Embodiment of the no-nonsense personality, 19-year old (as shown on her profile shown in episode 7) Inspector Re-l Mayer of the Citizen Intelligence Bureau is in charge of investigating a series of brutal murders apparently committed by AutoReivs infected with the Cogito virus. She is also the granddaughter of Donov Mayer, the Regent of Romdo. Given her privileged status, she expects respect from people around her, and speaks as such (she addresses Vincent as "o-mae"). Re-l accompanies Vincent on his journey in order to learn more about the mysterious Proxies, but having been living in comfortable conditions and being spoilt by Iggy all her life, she finds the "outdoor hiking" experience increasingly unbearable, and throws tantrums at both of them (often with comical effects). During the period that they get stranded without wind, she passes time by taking the both of them as study subjects. Her narration reveals her to be a very analytical person. Re-l is a young woman who wears black clothes, has black hair and is known for her blue eyeshadow. She eventually comes to share Vincent's feelings, but shows it subtly. (Source: Wikipedia)

Also known as Nodame, which is a portmanteau of her family name and the first mora of her given name. Noda is, at the start of the series, a twenty-year-old free-spirited second-year music student. She is depicted as a complete slob: her cooking and cleaning skills are atrocious to the point of having mushrooms growing on her clothes and poisoning anyone who dares to eat her food (yet she's never been poisoned). However she is an incredibly talented pianist who primarily plays by ear, in a cantabile style. In love with Chiaki, she follows him around constantly, claiming to be his "wife," and leans on him to help her get through sticky situations. She sometimes compulsively needs to play the piano, neglecting everything in order to do it. As well as that, she seems to enjoy childish manga and movies. She is constantly hungry, and is fed dinners by Chiaki; she also steals many lunches from her fellow friend, Maki. Nodame has a tendency to speak cryptically (sometimes she doesn't even understand herself), often refers to herself in the third person and uses nonsense words like mukya and gyabo. Nodame is initially very dependent on Chiaki in terms of ambition - she has little intention of becoming a professional pianist, despite her remarkable talent, and wants to become a kindergarten teacher, though many feel she is too reckless and lacks the appropriate sensibility to be responsible with teaching children. Her piano style is considered to be completely haphazard, diverting from original intent at both dynamics, rhythms and even themes. Realizing that her current attitude towards music will eventually drive her apart from Chiaki, Nodame gradually develops the necessary drive to pursue music for her own sake. Her attitude towards music is largely due to an incident in the past where she was hurt by a teacher who demanded her to play music "as it's written." Nodame's character is based on a real-life counterpart with same name.